NOTICE OF INTENT TO SOLE SOURCE This notice is being published in accordance with Federal Acquisition Regulation (FAR) Subpart 5.101 requiring dissemination of information for proposed contract actions. This is a notice of intent to award a sole source contract, and is not a request for competitive quotes/proposals. The statutory authority for this sole source procurement is prescribed by FAR 13.501(a).

The National Institutes of Health (NIH), NINR intends to award a sole source, firm-fixed priced purchase order for one year to Quaterix for annual service maintenance contract for the SIMOA HD- The mission of NINR is to promote and improve the health of individuals, families, communities, and populations. NINR supports and conducts clinical and basic research and research training on health and illness across the lifespan. The research focus encompasses health promotion and disease prevention, quality of life, health disparities, and end-of-life. X Analyzer. It is necessary to ensure proper working order and accuracy of instrument for experiments.

The Simoa HD-X Analyzer allows for detection of thousands of single protein molecules simultaneously using the same reagents as the current standard method for detecting proteins, ELISA. Single protein molecules are captured and labeled on beads using standard ELISA reagents. The Simoa HD-X Analyzer uses arrays of femtoliter-sized reaction chambers that can isolate and detect single enzyme molecules. After fluorescent labeling of the proteins, The Simoa HD-X Analyzer enables protein concentrations to be determined digitally rather than by using the total analog signal, called digital ELISA. By isolating and detecting single immunocomplexes in arrays of femtoliter-volume wells, digital ELISA 2 enables clinically important proteins in serum to be measured at subfemtomolar concentrations that allows peripheral samples of blood to approximate central activity of neuropeptides.

However, all responsible sources may submit a capability statement demonstrating the ability to provide the requested services, which shall be considered by the agency before the intended award date. Interested sources who submit data are responsible for appropriately marking information if it is proprietary in nature. The Government shall not reimburse interested sources for any information provided. No requests for capability briefings will be honored. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Interested vendors must respond to this notice on or before December 26 ,2022 at 11:00 am Eastern Time by sending an email to holleyv@od.nih.gov . NAICS Code: 334516- Laboratory Equipment and Supplies.